S1PR1 anticorps (AA 51-150)

N° du produit ABIN872844

Détail du produit anti-S1PR1 anticorps

Antigène: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Épitope: AA 51-150

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp S1PR1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human S1P1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-S1PR1 (ABIN872844)

Xiao, Fu, Xu, Feng, Sun, Ye: "Fingolimod Suppresses a Cascade of Core Vicious Cycle in Dry Eye NOD Mouse Model: Involvement of Sphingosine-1-Phosphate Receptors in Infiltrating Leukocytes." dans: Investigative ophthalmology & visual science, Vol. 58, Issue 14, pp. 6123-6132, (2017) (PubMed).

Détails sur S1PR1

Antigène: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Autre désignation: S1P1 (S1PR1 Produits)

Synonymes: anticorps CD363, anticorps CHEDG1, anticorps D1S3362, anticorps ECGF1, anticorps EDG-1, anticorps EDG1, anticorps S1P1, anticorps AI849002, anticorps Edg1, anticorps Lpb1, anticorps S1p, anticorps S1p1, anticorps S1P receptor 1, anticorps S1P receptor Edg-1, anticorps edg1, anticorps etID43307.22, anticorps s1p1, anticorps wu:fb98f05, anticorps s1pr1, anticorps xts1p1, anticorps sphingosine-1-phosphate receptor 1, anticorps sphingosine-1-phosphate receptor 1 L homeolog, anticorps S1PR1, anticorps S1pr1, anticorps s1pr1, anticorps s1pr1.L

Sujet:

Synonyms: EDG1, S1P1, CD363, ECGF1, EDG-1, CHEDG1, D1S3362, Sphingosine 1-phosphate receptor 1, S1P receptor 1, Endothelial differentiation G-protein coupled receptor 1, Sphingosine 1-phosphate receptor Edg-1, S1P receptor Edg-1, S1PR1

Background: G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.

ID gène: 1901

UniProt: P21453

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2