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NET1 anticorps (AA 501-596)

NET1 Reactivité: Humain, Souris WB, IF (p), IF (cc), IHC (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN873108
  • Antigène Voir toutes NET1 Anticorps
    NET1 (Neuroepithelial Cell Transforming 1 (NET1))
    Épitope
    • 15
    • 8
    • 7
    • 6
    • 6
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 501-596
    Reactivité
    • 46
    • 37
    • 14
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 57
    • 2
    • 1
    • 1
    Lapin
    Clonalité
    • 60
    • 1
    Polyclonal
    Conjugué
    • 24
    • 6
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp NET1 est non-conjugé
    Application
    • 32
    • 24
    • 14
    • 13
    • 5
    • 4
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Humain, Souris
    Homologie
    Rat,Dog,Cow,Horse,Chicken
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human NET1
    Isotype
    IgG
    Top Product
    Discover our top product NET1 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    NET1 (Neuroepithelial Cell Transforming 1 (NET1))
    Autre désignation
    Net1 (NET1 Produits)
    Synonymes
    anticorps arhgef8, anticorps net1a, anticorps xNET1, anticorps DKFZp459I0423, anticorps NET1, anticorps ARHGEF8, anticorps NET1A, anticorps 0610025H04Rik, anticorps 9530071N24Rik, anticorps AI604373, anticorps AU015857, anticorps Net1a, anticorps mNET1, anticorps wu:fb13g03, anticorps wu:fb25c11, anticorps zgc:92121, anticorps neuroepithelial cell transforming 1, anticorps neuroepithelial cell-transforming gene 1 protein, anticorps neuroepithelial cell transforming 1 L homeolog, anticorps neuroepithelial cell transforming gene 1, anticorps net1, anticorps EDI_348570, anticorps NET1, anticorps Net1, anticorps net1.L
    Sujet

    Synonyms: NAT1, NET, NET, NET1, Norepinephrine transporter, SLC6A2, SLC6A5, SLC6A5, Sodium dependent noradrenaline transporter, Solute carrier family 6 neurotransmitter transporter norepinephrine member 5, Solute carrier family 6 member 2, Solute carrier family 6 member 2.

    Background: Catecholamine, a term used for the hormone adrenaline and its sequentially hydroxylated form noradrenaline, is involved in fight or flight responses. Noradrenaline is released from the post ganglionic sympathetic nerve endings and exerts its effects locally in the immediate vicinity of its release. In the CNS, noradrenaline is involved in a number of physiological responses including mood, sleep regulation, alertness and arousal, both cognitive and non-cognitive expression of behaviors, and control of the endocrine and autonomic nervous systems. Peripherally, noradrenaline is present in sympathetic nerve endings and has full control of the sympathetic nervous system. Noradrenaline released from pre-synaptic nerve terminals is reabsorbed (70-90 % ) by noradrenaline transporters and its biological effects are terminated. The noradrenaline transport via noradrenaline transporters is an active, Na+/Cl- dependent transport process mediated by noradrenaline transporters. Noradrenaline transporters constitute the primary mechanism for inactivation of synaptically released noradrenaline, are targets for multiple antidepressants and psychostimulants, and are deficient in affective and autonomic disorders. In rat brain, noradrenaline transporter is expressed in noradrenergic neuronal somata, axons and dendrites, and hippocampus and cortex, but is absent from epinephrine- and dopamine-containing neurons. At least 13 genetic variations have been reported in the noradrenaline transporter protein that affect noradrenaline re-uptake and concentrations in cerebrospinal fluid in humans. The association between these genetic variations in noradrenaline transporters and several psychiatric and cardiovascular disorders is just emerging. Recently, a single amino acid mutation (hNET-A457P) showed deficiency in noradrenaline transport in an orthostatic intolerance patient.

    ID gène
    10276
    Pathways
    Neurotrophin Signaling Pathway
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