SAMHD1 anticorps (AA 256-370)

N° du produit ABIN873131

Détail du produit anti-SAMHD1 anticorps

Antigène: SAMHD1 (SAM Domain and HD Domain 1 (SAMHD1))

Épitope: AA 256-370

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SAMHD1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Souris

Homologie: Human,Rat,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SAMHD1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur SAMHD1

Antigène: SAMHD1 (SAM Domain and HD Domain 1 (SAMHD1))

Autre désignation: SAMHD1 (SAMHD1 Produits)

Synonymes: anticorps CHBL2, anticorps DCIP, anticorps HDDC1, anticorps MOP-5, anticorps SBBI88, anticorps si:dkeyp-44b8.8, anticorps E330031J07Rik, anticorps Mg11, anticorps SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1, anticorps SAM domain and HD domain 1, anticorps SAM domain and HD domain, 1, anticorps SAMHD1, anticorps samhd1, anticorps Samhd1

Sujet:

Synonyms: DCIP, Dendritic cell derived NG induced protein, Dendritic cell-derived NG-induced protein, HD domain containing 1, HDDC1, Mg11, Monocyte protein 5, MOP 5, MOP5, OTTHUMP00000030889, SAM domain and HD domain 1, SAM domain and HD domain containing protein 1, SAM domain and HD domain-containing protein 1, SAMH1_HUMAN, Samhd1, SBBI88.

Background: Putative nuclease involved in innate immune response by acting as a negative regulator of the cell-intrinsic antiviral response. May play a role in mediating proinflammatory responses to TNF-alpha signaling.Tissue specificity:Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. No expression is seen in brain and thymus.Involvement in disease:Defects in SAMHD1 are the cause of Aicardi-Goutieres syndrome type 5 (AGS5) . A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood.

ID gène: 4861

UniProt: Q9Y3Z3