BMP1 anticorps

N° du produit ABIN873233

Détail du produit anti-BMP1 anticorps

Antigène: BMP1 (Bone Morphogenetic Protein 1 (BMP1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BMP1 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human BMP1

Isotype: IgG

Information d'application

Indications d'application: WB: (1:100-1000), IHC-P: (1:100-500), IF(IHC-P): (1:50-200)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur BMP1

Antigène: BMP1 (Bone Morphogenetic Protein 1 (BMP1))

Autre désignation: Bmp1 (BMP1 Produits)

Synonymes: anticorps OI13, anticorps PCOLC, anticorps PCP, anticorps PCP2, anticorps TLD, anticorps Pcp, anticorps Tld, anticorps BMP1, anticorps submp, anticorps tld, anticorps xtld, anticorps bmp-1, anticorps pcolc, anticorps xbmp1, anticorps tolloid, anticorps BMP-1, anticorps bmp1, anticorps bmp1a, anticorps bone morphogenetic protein 1, anticorps Bone morphogenetic protein 1, anticorps bone morphogenetic protein 1 S homeolog, anticorps bone morphogenetic protein 1, like, anticorps BMP1, anticorps Bmp1, anticorps bmp1, anticorps bmp1.S, anticorps bmp1l

Sujet:

Synonyms: BMP 1, BMP-1, Bone morphogenetic protein 1, Mammalian tolloid protein, mTld, PCOLC, PCP, ProCollagen C endopeptidase, Procollagen C proteinase, TLD, BMP1_HUMAN.

Background: Bone morphogenetic protein 1 (BMP1) was first identified in osteogenic extracts of bone. It is an extracellular zinc endopeptidase, implicated in morphogenetic processes in a broad range of species. BMP1 is a member of the astacin family of metalloproteinases. The astacin family includes BMP1, astacin, meprin A and B, tolloid-like proteins, and choriolysin. BMP1 is involved in extracellular matrix (ECM) formation, suggesting that a functional link may exist between astacin metalloproteinases, growth factors, and cell differentiation and pattern formation during development. The name PCP reflects this enzyme’s involvement in the collagen deposition of growing bone. The enzymes known as the procollagen C and N proteinases (PCP and PNP) are involved in the processing of fibrillar procollagen precursors to mature collagens, which is an essential requirement for fibril formation. PCP cleaves the C-terminus from procollagen, to allow the formation of mature, triplehelical collagen. The N-terminus is cleaved by the procollagen N-proteinase (PNP or ADAM-TS2). Defects in PNP have been linked to the skin disorder dermatosparaxis, and defects in BMP1 are thought to lead to aberrant collagen processing, and connective tissue disorders. Many forms of BMP1 have been reported, with varying truncation at the C-terminus. The long form of BMP1 is most similar to the tolloid-like proteins, which have extra EGF-like and CUB domains.

ID gène: 649

Pathways: Lipid Metabolism