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Lipin 1 anticorps (AA 501-600)

LPIN1 Reactivité: Rat IF (cc), IF (p), ELISA, IHC (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN873246
  • Antigène Voir toutes Lipin 1 (LPIN1) Anticorps
    Lipin 1 (LPIN1)
    Épitope
    • 15
    • 15
    • 14
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 501-600
    Reactivité
    • 58
    • 44
    • 34
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Rat
    Hôte
    • 71
    • 8
    • 3
    Lapin
    Clonalité
    • 66
    • 16
    Polyclonal
    Conjugué
    • 26
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp Lipin 1 est non-conjugé
    Application
    • 39
    • 39
    • 19
    • 17
    • 15
    • 9
    • 8
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Rat
    Homologie
    Human,Mouse,Dog,Cow,Sheep,Pig,Rabbit,Chimpanzee,Goose
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human Lipin 1
    Isotype
    IgG
    Top Product
    Discover our top product LPIN1 Anticorps primaire
  • Indications d'application
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    Lipin 1 (LPIN1)
    Autre désignation
    Lipin 1 (LPIN1 Produits)
    Synonymes
    anticorps LPIN1, anticorps pap1, anticorps PAP1, anticorps 4631420P06, anticorps Kiaa0188, anticorps Lipin1, anticorps fld, anticorps mKIAA0188, anticorps zgc:194552, anticorps zgc:194558, anticorps lipin1, anticorps lipin 1, anticorps phosphatidate phosphatase LPIN1, anticorps LPIN1, anticorps lpin1, anticorps LOC100539289, anticorps Lpin1
    Sujet

    Synonyms: KIAA0188, LPIN1, PAP1, Phosphatidate phosphatase LPIN1, LPIN1_HUMAN.

    Background: Lipin 1 is a member of the Lipin family of nuclear proteins. This family contains three members: Lipin 1, Lipin 2 and Lipin 3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin 1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC1 alpha target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARalpha. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.

    ID gène
    23175
    Pathways
    Monocarboxylic Acid Catabolic Process
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