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Complement C3c anticorps (AA 1051-1200)

C3C Reactivité: Humain, Rat, Porc ELISA, WB, ICC, IHC (fro), IHC (p), IF (p), IF (cc) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN873279
  • Antigène Tous les produits Complement C3c (C3C)
    Complement C3c (C3C) (Complement Component C3c (C3C))
    Épitope
    • 14
    • 3
    • 2
    AA 1051-1200
    Reactivité
    • 60
    • 27
    • 16
    • 15
    • 14
    • 12
    • 5
    • 4
    • 3
    • 1
    Humain, Rat, Porc
    Hôte
    • 71
    • 26
    • 10
    • 9
    • 2
    • 2
    Lapin
    Clonalité
    • 114
    • 4
    Polyclonal
    Conjugué
    • 36
    • 34
    • 16
    • 14
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Complement C3c est non-conjugé
    Application
    • 70
    • 51
    • 32
    • 30
    • 26
    • 19
    • 13
    • 13
    • 12
    • 12
    • 11
    • 7
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
     Réactivité croisée
    Humain, Porc, Rat
    Homologie
    Mouse,Dog
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human Complement C3c alpha' chain fragment 1
    Isotype
    IgG
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Vass, Süveges, Érces, Nógrády, Varga, Földesi, Futakuchi, Imai, Okada, Okada, Boros, Kaszaki: "Inflammatory activation after experimental cardiac tamponade." dans: European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes, Vol. 51, Issue 1-2, pp. 1-13, (2013) (PubMed).

  • Antigène
    Complement C3c (C3C) (Complement Component C3c (C3C))
    Autre désignation
    Complement Fragment 3c (C3C Produits)
    Sujet

    Synonyms: ASP, C3a, C3b, AHUS5, ARMD9, CPAMD1, HEL-S-62p, Complement C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, C3

    Background: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (PubMed:837664, PubMed:29953, PubMed:959512, PubMed:1432298, PubMed:15833747, PubMed:16333141, PubMed:1961575).

    ID gène
    718
    UniProt
    P01024
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