SHP1 anticorps (pTyr536) (AbBy Fluor® 647)
-
- Antigène Voir toutes SHP1 (PTPN6) Anticorps
- SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))
-
Épitope
- pTyr536
-
Reactivité
- Humain, Souris
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp SHP1 est conjugé à/à la AbBy Fluor® 647
-
Application
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- Réactivité croisée
- Humain, Souris
- Homologie
- Dog,Horse
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic phosphopeptide derived from human PTPN6 around the phosphorylation site of Tyr536 [SE(p-Y)GN]
- Isotype
- IgG
- Top Product
- Discover our top product PTPN6 Anticorps primaire
-
-
- Indications d'application
-
FCM 1:20-100
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
-
-
Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages." dans: The Journal of cell biology, Vol. 216, Issue 4, pp. 1123-1141, (2017) (PubMed).
: "
-
Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages." dans: The Journal of cell biology, Vol. 216, Issue 4, pp. 1123-1141, (2017) (PubMed).
-
- Antigène
- SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))
- Autre désignation
- PTPN6 (PTPN6 Produits)
- Synonymes
- anticorps HCPH, anticorps HPTP1C, anticorps PTP-1C, anticorps SH-PTP1, anticorps SHP-1, anticorps SHP-1L, anticorps SHP1, anticorps DRPLA, anticorps Hcph, anticorps Ptp1C, anticorps me, anticorps motheaten, anticorps Ptph6, anticorps Shp-1, anticorps fj22f05, anticorps wu:fj22f05, anticorps zgc:55501, anticorps ptpn6, anticorps protein tyrosine phosphatase, non-receptor type 6, anticorps protein tyrosine phosphatase, non-receptor type 6 L homeolog, anticorps PTPN6, anticorps Ptpn6, anticorps ptpn6, anticorps ptpn6.L
- Sujet
-
Synonyms: SHP-1Tyr536, PTPN6phospho Y536, SHP1phospho Y536, 70 kda SHP1L protein, HCP, HCPH, Hematopoietic cell phosphatase, Hematopoietic cell protein tyrosine phosphatase, Hematopoietic cell protein-tyrosine phosphatase, HPTP1C, Protein tyrosine phosphatase 1C, Protein tyrosine phosphatase non receptor type 6, Protein tyrosine phosphatase SHP1, PTP1C, PTPN6, SH PTP 1, SHP1, SHP1L, PTN6_HUMAN.
Background: SHP1 is a member of the non receptor protein tyrosine phosphatase subfamily. The PTP family comprises of at least 37 proteins, characterized by a catalytic phosphatase domain of approximately 240 amino acids, and includes both transmembrane and cytosolic enzymes. PTP1B is cytosolic. The PTPs have high substrate specificity for phosphotyrosyl proteins, at the primary sequence level sharing little similarity with the protein serine phosphatases, protein threonine phosphatases, or the acid and alkaline phosphatases. SHP1 is implicated in the control of tyrosine kinase signalling pathways in cellular proliferation, with a potential role in cancer.
- ID gène
- 5777
- UniProt
- P29350
- Pathways
- Signalistation JAK/STAT, TCR Signaling, Signalisation TLR, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, BCR Signaling
-