AF4 anticorps (AA 31-130) (AbBy Fluor® 350)
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- Antigène Tous les produits AF4 (AFF1)
- AF4 (AFF1) (AF4/FMR2 Family, Member 1 (AFF1))
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Épitope
- AA 31-130
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp AF4 est conjugé à/à la AbBy Fluor® 350
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Application
- Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- Homologie
- Human,Mouse,Rat,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human AF 4 protein
- Isotype
- IgG
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- AF4 (AFF1) (AF4/FMR2 Family, Member 1 (AFF1))
- Autre désignation
- AF4 (AFF1 Produits)
- Synonymes
- anticorps AF4, anticorps MLLT2, anticorps PBM1, anticorps 9630032B01Rik, anticorps AW319193, anticorps Af4, anticorps Mllt2h, anticorps Rob, anticorps Mllt2, anticorps AF4/FMR2 family member 1, anticorps AF4/FMR2 family, member 1, anticorps AFF1, anticorps Aff1
- Sujet
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Synonyms: AF 4, AF 4 protein, AF-4 protein, AF4/FMR2 family member 1, AFF 1, AFF1, AFF1_HUMAN, ALL1 fused gene from chromosome 4, ALL1-fused gene from chromosome 4 protein, FEL, MLLT2, MYELOID/LYMPHOID OR MIXED LINEAGE LEUKEMIA TRANSLOCATED TO 2, MLLT2, Protein AF-4, Protein FEL, Proto-oncogene AF4.
Background: Proto-oncogene AF-4 (or FEL) is a product of a chromosomal aberration of the human gene AFF1, which is associated with acute leukemias. The fusion of AF-4 on chromosome band 4q21 with the mixed lineage leukemia (MLL or HRX) gene on 11q23 results in a MLL-AF-4 chimeric transcription factor in which AF-4 contributes transcriptional effector properties and requires cell-specific accessory factors. MLL is involved in several chromosomal translocations associated with acute myeloid and lymphoid leukemia. The MLL-AF-4 fusion protein is expressed in all normal hematopoietic cells. The expression of MLL-AF-4 influences the production of protein cyclin-dependent kinase inhibitor (CDKN1B), suggesting that inhibition of MLL-AF-4 expression may be a powerful and highly specific treatment of chemotherapy-resistant leukemia.
- ID gène
- 4299
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