CUBN anticorps (AA 51-150) (AbBy Fluor® 350)
-
- Antigène Voir toutes CUBN Anticorps
- CUBN (Cubilin (Intrinsic Factor-Cobalamin Receptor) (CUBN))
-
Épitope
- AA 51-150
-
Reactivité
- Humain
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp CUBN est conjugé à/à la AbBy Fluor® 350
-
Application
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Humain
- Homologie
- Mouse,Rat
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human Cubilin
- Isotype
- IgG
- Top Product
- Discover our top product CUBN Anticorps primaire
-
-
- Indications d'application
-
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
-
- Antigène
- CUBN (Cubilin (Intrinsic Factor-Cobalamin Receptor) (CUBN))
- Autre désignation
- Cubilin (CUBN Produits)
- Synonymes
- anticorps GP280, anticorps IFCR, anticorps MGA1, anticorps AA408369, anticorps AL022750, anticorps D2Wsu88e, anticorps gp280, anticorps cubilin, anticorps cubilin (intrinsic factor-cobalamin receptor), anticorps LOC411053, anticorps CUBN, anticorps cubn, anticorps Cubn
- Sujet
-
Synonyms: IFCR, MGA1, gp280, Cubilin, 460 kDa receptor, Intestinal intrinsic factor receptor, Intrinsic factor-cobalamin receptor, Intrinsic factor-vitamin B12 receptor, CUBN
Background: Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.
- ID gène
- 8029
- UniProt
- O60494
- Pathways
- Metabolism of Steroid Hormones and Vitamin D, Lipid Metabolism
-