TDP2 anticorps (AA 201-300) (AbBy Fluor® 488)
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- Antigène Voir toutes TDP2 Anticorps
- TDP2 (tyrosyl-DNA phosphodiesterase 2 (TDP2))
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Épitope
- AA 201-300
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Reactivité
- Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TDP2 est conjugé à/à la AbBy Fluor® 488
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Souris
- Homologie
- Human,Rat,Dog,Cow,Pig,Horse,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human ETS1 associated protein II/EAPII
- Isotype
- IgG
- Top Product
- Discover our top product TDP2 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- TDP2 (tyrosyl-DNA phosphodiesterase 2 (TDP2))
- Autre désignation
- ETS1 associated protein 2 (TDP2 Produits)
- Synonymes
- anticorps AD022, anticorps EAP2, anticorps EAPII, anticorps TTRAP, anticorps dJ30M3.3, anticorps hTDP2, anticorps ad022, anticorps eap2, anticorps ttrap, anticorps D13Ertd656e, anticorps Ttrap, anticorps tdp2, anticorps ttrapl, anticorps tyrosyl-DNA phosphodiesterase 2, anticorps tyrosyl-DNA phosphodiesterase 2 S homeolog, anticorps tyrosyl-DNA phosphodiesterase 2b, anticorps TDP2, anticorps tdp2.S, anticorps Tdp2, anticorps tdp2b
- Sujet
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Synonyms: EAP 2, EAP II, EAP2, EAPII, ETS 1 associated protein 2, ETS 1 associated protein II, ETS1 associated protein 2, ETS1-associated protein 2, ETS1-associated protein II, tdp2, TRAF and TNF receptor associated protein, TRAF and TNF receptor-associated protein, TTRAP, TYDP2_HUMAN, Tyr DNA phosphodiesterase 2, Tyr-DNA phosphodiesterase 2, Tyrosyl DNA phosphodiesterase 2, Tyrosyl-DNA phosphodiesterase 2, 5''-Tyr-DNA phosphodiesterase, 5''-tyrosyl-DNA phosphodiesterase, AD 022, AD022, MGC111021, MGC9099.
Background: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.
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