HDAC2 anticorps (AA 391-488) (AbBy Fluor® 350)

N° du produit ABIN900333

Détail du produit anti-HDAC2 anticorps (AbBy Fluor® 350)

Antigène: HDAC2 (Histone Deacetylase 2 (HDAC2))

Épitope: AA 391-488

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HDAC2 est conjugé à/à la AbBy Fluor® 350

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Réactivité croisée: Humain, Souris, Rat

Homologie: Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human HDAC2

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur HDAC2

Antigène: HDAC2 (Histone Deacetylase 2 (HDAC2))

Autre désignation: Hdac2/Hd2 (HDAC2 Produits)

Synonymes: anticorps HD2, anticorps RPD3, anticorps YAF1, anticorps D10Wsu179e, anticorps Yy1bp, anticorps mRPD3, anticorps HISTONE DEACETYLASE, anticorps T1N24.9, anticorps T1N24_9, anticorps histone deacetylase 2, anticorps histone deacetylase 2, anticorps histone deacetylase 2 S homeolog, anticorps HDAC2, anticorps Hdac2, anticorps hdac2.S, anticorps HDA2

Sujet:

Synonyms: HD2, RPD3, YAF1, Histone deacetylase 2, HDAC2

Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.

ID gène: 3066

UniProt: Q92769

Pathways: Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2