NLRP4 anticorps (AA 351-450) (Cy7)

N° du produit ABIN907635

Détail du produit anti-NLRP4 anticorps (Cy7)

Antigène: NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))

Épitope: AA 351-450

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NLRP4 est conjugé à/à la Cy7

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Specificité: This antibody will detect multiple forms of NALP4, including the A, C and E Mouse variants.

Réactivité croisée: Humain, Rat

Homologie: Mouse,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human NALP4

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur NLRP4

Antigène: NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))

Autre désignation: NALP4 (NLRP4 Produits)

Sujet:

Synonyms: NACHT, LRR and PYD domains-containing protein 4, Cancer/testis antigen 58, CT58, PAAD and NACHT-containing protein 2, PAN2, PYRIN and NACHT-containing protein 2, PYRIN-containing APAF1-like protein 4, PYPAF4, Ribonuclease inhibitor 2, NLRP4, NALP4, RNH2

Background: May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.

ID gène: 147945

UniProt: Q96MN2

Pathways: Inflammasome