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NLRP4 anticorps (AA 351-450) (HRP)

NLRP4 Reactivité: Humain, Rat ELISA, IHC (fro), IHC (p) Hôte: Lapin Polyclonal HRP
N° du produit ABIN907644
  • Antigène Voir toutes NLRP4 Anticorps
    NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))
    Épitope
    • 14
    • 8
    • 7
    • 6
    • 1
    • 1
    AA 351-450
    Reactivité
    • 36
    • 14
    • 2
    Humain, Rat
    Hôte
    • 36
    Lapin
    Clonalité
    • 36
    Polyclonal
    Conjugué
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp NLRP4 est conjugé à/à la HRP
    Application
    • 16
    • 16
    • 13
    • 13
    • 2
    • 2
    • 1
    ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    This antibody will detect multiple forms of NALP4, including the A, C and E Mouse variants.
     Réactivité croisée
    Humain, Rat
    Homologie
    Mouse,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human NALP4
    Isotype
    IgG
    Top Product
    Discover our top product NLRP4 Anticorps primaire
  • Indications d'application
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Conseil sur la manipulation
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))
    Autre désignation
    NALP4 (NLRP4 Produits)
    Synonymes
    anticorps CLR19.5, anticorps CT58, anticorps NALP4, anticorps PAN2, anticorps PYPAF4, anticorps RNH2, anticorps Nalp4, anticorps Nlrp4e, anticorps RGD1563529, anticorps NLR family pyrin domain containing 4, anticorps NLR family, pyrin domain containing 4, anticorps NLRP4, anticorps Nlrp4
    Sujet

    Synonyms: NACHT, LRR and PYD domains-containing protein 4, Cancer/testis antigen 58, CT58, PAAD and NACHT-containing protein 2, PAN2, PYRIN and NACHT-containing protein 2, PYRIN-containing APAF1-like protein 4, PYPAF4, Ribonuclease inhibitor 2, NLRP4, NALP4, RNH2

    Background: May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.

    ID gène
    147945
    UniProt
    Q96MN2
    Pathways
    Inflammasome
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