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RNF126 anticorps (AA 51-150) (AbBy Fluor® 555)

RNF126 Reactivité: Humain, Souris WB, IF (cc), IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 555
N° du produit ABIN913807
  • Antigène Voir toutes RNF126 Anticorps
    RNF126 (Ring Finger Protein 126 (RNF126))
    Épitope
    • 14
    • 6
    • 2
    • 1
    • 1
    • 1
    AA 51-150
    Reactivité
    • 32
    • 19
    • 4
    • 2
    • 2
    • 1
    • 1
    Humain, Souris
    Hôte
    • 31
    • 1
    Lapin
    Clonalité
    • 31
    • 1
    Polyclonal
    Conjugué
    • 9
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp RNF126 est conjugé à/à la AbBy Fluor® 555
    Application
    • 22
    • 12
    • 12
    • 10
    • 3
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Humain, Souris
    Homologie
    Rat,Cow
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human RNF126
    Isotype
    IgG
    Top Product
    Discover our top product RNF126 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    RNF126 (Ring Finger Protein 126 (RNF126))
    Autre désignation
    Rnf126 (RNF126 Produits)
    Synonymes
    anticorps 2610010O19Rik, anticorps ring finger protein 126, anticorps RNF126, anticorps Rnf126
    Sujet

    Synonyms: E3 ubiquitin-protein ligase RNF126, RING finger protein 126, RNF126

    Background: E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).

    ID gène
    55658
    UniProt
    Q9BV68
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