ITGAL anticorps

N° du produit ABIN93953

Détail du produit anti-ITGAL anticorps

Antigène: ITGAL (Integrin alpha-L (ITGAL))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ITGAL est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP)

Specificité: The antibody MEM-83 reacts with an extracellular epitope of CD11a (alpha subunit of human LFA-1), a 170-180 kDa type I transmembrane glycoprotein expressed on B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils.

Réactivité croisée (Details): Human

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Human peripheral blood lymphocytes

Clone: MEM-83

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 1 μg/mL.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-ITGAL (ABIN93953)

Landis, McDowall, Holness, Littler, Simmons, Hogg: "Involvement of the "I" domain of LFA-1 in selective binding to ligands ICAM-1 and ICAM-3." dans: The Journal of cell biology, Vol. 126, Issue 2, pp. 529-37, (1994) (PubMed).

Landis, Bennett, Hogg: "A novel LFA-1 activation epitope maps to the I domain." dans: The Journal of cell biology, Vol. 120, Issue 6, pp. 1519-27, (1993) (PubMed).

Détails sur ITGAL

Antigène: ITGAL (Integrin alpha-L (ITGAL))

Autre désignation: CD11a (ITGAL Produits)

Synonymes: anticorps CD11A, anticorps LFA-1, anticorps LFA1A, anticorps (p180), anticorps Cd11a, anticorps LFA-1A, anticorps Ly-15, anticorps Ly-21, anticorps CD11a, anticorps ITGAL, anticorps integrin subunit alpha L, anticorps integrin alpha L, anticorps ITGAL, anticorps Itgal

Sujet: Integrin subunit alpha L,CD11a (LFA-1 alpha) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions. Blocking of LFA-1 function by specific antibodies or small molecules has become an important therapeutic approach in treatment of multiple inflammatory diseases. For example, humanized anti-LFA-1 antibody Efalizumab (Raptiva) is being used to interfere with T cell migration to sites of inflammation, binding of cholesterol-lowering drug simvastatin to CD11a allosteric site leads to immunomodulation and increase in lymphocytic cholinergic activity.,LFA-1, LFA1A, ITGAL

ID gène: 3683

UniProt: P20701

Pathways: Activated T Cell Proliferation, Integrin Complex