CD21 anticorps

N° du produit ABIN94032

Détail du produit anti-CD21 anticorps

Antigène: CD21 (CR2) (Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2))

Reactivité: Humain, Porc, Boeuf (Vache), Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD21 est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: The antibody LT21 reacts with an extracellular epitope of CD21 (CR2), a 145 kDa transmembrane glycoprotein (complement C3d receptor - C3dR) expressed on B lymphocytes, follicular dendritic cells, some epithelial cells and a subsets of T lymphocytes. It is not expressed on immature B cells.

Réactivité croisée (Details): Human, Porcine, Bovine, Canine (Dog)

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: IM9 human B-lymphoblastoid cell line

Clone: LT21

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 1-5 μg/mL.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-CD21 (ABIN94032)

Kulka, Brennan, Mc Gee: "Investigation of canine extracellular vesicles in diffuse large B-cell lymphomas." dans: PloS one, Vol. 17, Issue 9, pp. e0274261, (2022) (PubMed).

Faldyna, Samankova, Leva, Cerny, Oujezdska, Rehakova, Sinkora: "Cross-reactive anti-human monoclonal antibodies as a tool for B-cell identification in dogs and pigs." dans: Veterinary immunology and immunopathology, Vol. 119, Issue 1-2, pp. 56-62, (2007) (PubMed).

Filatov, Krotov, Zgoda, Volkov: "Fluorescent immunoprecipitation analysis of cell surface proteins: a methodology compatible with mass-spectrometry." dans: Journal of immunological methods, Vol. 319, Issue 1-2, pp. 21-33, (2007) (PubMed).

Détails sur CD21

Antigène: CD21 (CR2) (Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2))

Autre désignation: CD21 (CR2 Produits)

Synonymes: anticorps C3DR, anticorps CD21, anticorps CR, anticorps CVID7, anticorps SLEB9, anticorps Cd21, anticorps cd21, anticorps CR1, anticorps CR1-L, anticorps CR2, anticorps complement C3d receptor 2, anticorps complement C3b/C4b receptor 1 (Knops blood group), anticorps CR2, anticorps Cr2, anticorps CR1

Sujet: Complement C3d receptor 2,CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.,CR2, C3DR2, CVID7, SLEB9

ID gène: 1380

UniProt: P20023

Pathways: Système du Complément