ITGB1 anticorps

N° du produit ABIN94054

Détail du produit anti-ITGB1 anticorps

Antigène: ITGB1 (Integrin beta 1 (ITGB1))

Reactivité: Humain, Porc, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ITGB1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)

Specificité: The antibody MEM-101A reacts with an extracellular epitope of CD29 (integrin beta1 chain), a 130 kDa single chain type I glycoprotein expressed as a heterodimer (non-covalently associated with the integrin alpha subunits 1-6). CD29 is broadly expressed on majority of hematopoietic and non-hematopoietic cells (leukocytes, platelets, fibroblasts, endothelial cells, epithelial cells and mast cells).

Aucune reactivité croisée: Souris

Réactivité croisée (Details): Human, Porcine, Canine (Dog)

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Raji Burkitt's lymphoma cell line

Clone: MEM-101A

Isotype: IgG1

Information d'application

Indications d'application: Western blotting: Recommended dilution: 2 μg/mL, positive control: JURKAT human leukemia T-cell lysate, Kg-1a human leukemia cell lysate, non-reducing conditions, 6 % separating gel, 4 % stacking gel.
Flow cytometry: Recommended dilution: 2 μg/mL.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-ITGB1 (ABIN94054)

Plánka, Necas, Srnec, Rauser, Starý, Jancár, Amler, Filová, Hlucilová, Kren, Gál: "Use of allogenic stem cells for the prevention of bone bridge formation in miniature pigs." dans: Physiological research / Academia Scientiarum Bohemoslovaca, Vol. 58, Issue 6, pp. 885-93, (2010) (PubMed).

Símová, Klíma, Cermak, Sourková, Andera: "Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane." dans: Apoptosis : an international journal on programmed cell death, Vol. 13, Issue 3, pp. 423-36, (2008) (PubMed).

Détails sur ITGB1

Antigène: ITGB1 (Integrin beta 1 (ITGB1))

Autre désignation: CD29 (ITGB1 Produits)

Synonymes: anticorps CD29, anticorps FNRB, anticorps GPIIA, anticorps MDF2, anticorps MSK12, anticorps VLA-BETA, anticorps VLAB, anticorps 4633401G24Rik, anticorps AA409975, anticorps AA960159, anticorps ENSMUSG00000051907, anticorps Fnrb, anticorps Gm9863, anticorps gpIIa, anticorps cd29, anticorps fnrb, anticorps gpiia, anticorps itgb1, anticorps mdf2, anticorps msk12, anticorps vla-beta, anticorps vlab, anticorps itgb1-a, anticorps itgb1-b, anticorps integrin subunit beta 1, anticorps integrin beta 1 (fibronectin receptor beta), anticorps integrin subunit beta 1 S homeolog, anticorps integrin beta 1, anticorps integrin subunit beta 1 L homeolog, anticorps ITGB1, anticorps Itgb1, anticorps itgb1.S, anticorps LOC100009173, anticorps itgb1.L

Sujet: Integrin subunit beta 1,CD29 (beta1 integrin subunit, GPIIa) forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CD49a-f) determining the binding properties of beta1 (VLA) integrins. These integrins mediate cell adhesion to collagen, fibronectin, laminin and other extracellular matrix (ECM) components. This interaction hinders cell death, whereas disruption of anchorage to ECM leads to apoptosis. Decreased expression of most beta1 integrins correlates with acquiring multidrug resistance of tumour cells during selection in presence of antitumour drug. In platelets, translocation of intracellular pool of beta1 integrins to the plasma membrane following thrombin stimulation. These integrins are also up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue, as well as in regulating tissue damage and disease symptoms related to inflammatory bowel disease. Through a beta1 integrin-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta.,Integrin β,1 chain, ITGB1, VLAB, MDF2, FNRB, GPIIA, MSK12

ID gène: 3688

UniProt: P05556

Pathways: Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor, Integrin Complex, SARS-CoV-2 Protein Interactome