CD38 anticorps

N° du produit ABIN94083

Détail du produit anti-CD38 anticorps

Antigène: CD38

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD38 est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: The mouse monoclonal antibody HIT2 reacts with an extracellular epitope of CD38, a 45 kDa type II transmembrane glycoprotein strongly expressed mainly on plasma cells and activated T and B lymphocytes, it is an antigenic marker of lymphoid cells. Its binding is blocked by daratumumab.

Réactivité croisée (Details): Human

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Human thymocytes in foetus

Clone: HIT2

Isotype: IgG1

Information d'application

Indications d'application: Immunohistochemistry (paraffin sections): Recommended dilution: 10 μg/mL.
Western blotting: Recommended dilution: 2 μg/mL, positive control: RAJI human cell line, non-reducing conditions.
Flow cytometry: Recommended dilution: 1-4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-CD38 (ABIN94083)

Všianská, Říhová, Varmužová, Suská, Kryukov, Mikulášová, Kupská, Penka, Pour, Adam, Hájek: "Analysis of B-cell subpopulations in monoclonal gammopathies." dans: Clinical lymphoma, myeloma & leukemia, Vol. 15, Issue 4, pp. e61-71, (2015) (PubMed).

Rozková, Novotná, Pytlík, Hochová, Kozák, Bart?nková, Spísek: "Toll-like receptors on B-CLL cells: expression and functional consequences of their stimulation." dans: International journal of cancer. Journal international du cancer, Vol. 126, Issue 5, pp. 1132-43, (2010) (PubMed).

Kolar, Mehta, Pelayo, Capra: "A novel human B cell subpopulation representing the initial germinal center population to express AID." dans: Blood, Vol. 109, Issue 6, pp. 2545-52, (2007) (PubMed).

Détails sur CD38

Antigène: CD38

Abstract: CD38 Produits

Synonymes: anticorps T10, anticorps Cd38-rs1, anticorps cd38, anticorps ADPRC 1, anticorps cADPr hydrolase 1, anticorps CD38 molecule, anticorps CD38 antigen, anticorps CD38 molecule L homeolog, anticorps ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, anticorps CD38, anticorps Cd38, anticorps cd38.L

Sujet: CD38 Molecule,CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. Another role of CD38 is provided by enzymatic activity of its extracellular part. CD38 acts as NAD+ glycohydrolase converting NAD+ into ADP-ribose, as ADP-ribosyl cyclase producing cADPR and as cADPR hydrolase, thus affecting levels of calcium-mobilizing metabolites. ADPR produced by CD38 serves as an important second messenger of neutrophil and dendritic cell migration.,ADPRC1, cADPr hydrolase 1, T10, NAD(+) nucleosidase, ADP-ribosyl cyclase 1

ID gène: 952

UniProt: P28907