CD41, CD61 anticorps

N° du produit ABIN94110

Détail du produit anti-CD41, CD61 anticorps

Antigène: CD41, CD61 (CD41,CD61)

Reactivité: Humain, Boeuf (Vache)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD41, CD61 est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), ELISA, Immunocytochemistry (ICC)

Specificité: The antibody IVA30 reacts with an extracellular epitope on CD41/CD61 complex (bovine), one of the earliest markers of the megakaryocytic lineage. CD41/CD61 complex acts as the receptor for fibrinogen, fibronectin, Von Willebrand factor, vitronectin, thrombin and mediates platelets aggregation. CD41/CD61 is expressed only by platelets and megakaryocytes, the complex may be absent or strongly reduced in Glanzmann's thrombasthenia (GT). This antibody crossreacts with human platelets.

Réactivité croisée (Details): Human, Bovine

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Bovine trombocytes.

Clone: IVA30

Isotype: IgG2

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 1-4 μg/mL.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-CD41, CD61 (ABIN94110)

"Proceedings of the 3rd workshop on ruminant leukocyte antigens. Davis, California, 16 July 1995." dans: Veterinary immunology and immunopathology, Vol. 52, Issue 4, pp. 213-468, (1997) (PubMed).

Mateo, Perez de la Lastra, Moreno, Dusinsky, Bilka, Simon, Horovska, Llanes: "Biochemical characterization of antigens detected with anti-platelet monoclonal antibodies." dans: Veterinary immunology and immunopathology, Vol. 52, Issue 4, pp. 363-70, (1997) (PubMed).

Mateo, Pintado, Perez de la Lastra, Dusinsky, Simon, Naessens, Llanes: "Ruminant cluster CD41/CD61." dans: Veterinary immunology and immunopathology, Vol. 52, Issue 4, pp. 251-3, (1997) (PubMed).

Naessens, Howard, Hopkins: "Nomenclature and characterization of leukocyte differentiation antigens in ruminants." dans: Immunology today, Vol. 18, Issue 8, pp. 365-8, (1997) (PubMed).

Simon, Dusinsky, Horovska, Bilka, Hluchy: "Immunohistochemical reactivity of anti-platelet monoclonal antibodies." dans: Veterinary immunology and immunopathology, Vol. 52, Issue 4, pp. 377-82, (1997) (PubMed).

Détails sur CD41, CD61

Antigène: CD41, CD61 (CD41,CD61)

Abstract: CD41, CD61 Produits

Sujet: CD41 (platelet glycoprotein IIb, integrin alpha IIb) is composed of two subunits (120 kDa transmembrane alpha chain and 23 kDa extracellular beta chain) and interacts with CD61 (platelet glycoprotein IIIa, integrin beta 3) in the presence of calcium to form a functional adhesive protein receptor. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin, and it is involved in platelet aggregation.,platelet GPIIb, Integrin alpha-IIb, GPalpha IIb, GPIIb, GT, GP3A, platelet GPIIIa