CD46 anticorps (Biotin)
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- Antigène Voir toutes CD46 Anticorps
- CD46
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Reactivité
- Humain, Boeuf (Vache)
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CD46 est conjugé à/à la Biotin
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Application
- Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)
- Specificité
- The antibody MEM-258 recognizes an extracellular epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 kDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast, it is negative on erythrocytes.
- Réactivité croisée (Details)
- Human, Bovine
- Purification
- Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.
- Immunogène
- HPB-ALL human T cell line
- Clone
- MEM-258
- Isotype
- IgG1
- Top Product
- Discover our top product CD46 Anticorps primaire
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- Indications d'application
- Flow cytometry: Recommended dilution: 1-2 μg/mL.
- Commentaires
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The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
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Do not freeze.
Avoid prolonged exposure to light. - Stock
- 4 °C
- Stockage commentaire
- Store at 2-8°C. Do not freeze.
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Macropinocytotic uptake and infection of human epithelial cells with species B2 adenovirus type 35." dans: Journal of virology, Vol. 84, Issue 10, pp. 5336-50, (2010) (PubMed).
: "Fiber mediated receptor masking in non-infected bystander cells restricts adenovirus cell killing effect but promotes adenovirus host co-existence." dans: PLoS ONE, Vol. 4, Issue 12, pp. e8484, (2009) (PubMed).
: "Receptor usage of a newly emergent adenovirus type 14." dans: Virology, Vol. 387, Issue 2, pp. 436-41, (2009) (PubMed).
: "Evaluation of twenty-one human adenovirus types and one infectivity-enhanced adenovirus for the treatment of malignant melanoma." dans: The Journal of investigative dermatology, Vol. 128, Issue 4, pp. 988-98, (2008) (PubMed).
: "Species B adenovirus serotypes 3, 7, 11 and 35 share similar binding sites on the membrane cofactor protein CD46 receptor." dans: The Journal of general virology, Vol. 88, Issue Pt 11, pp. 2925-34, (2007) (PubMed).
: "Myeloid and plasmacytoid dendritic cells are susceptible to recombinant adenovirus vectors and stimulate polyfunctional memory T cell responses." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 3, pp. 1721-9, (2007) (PubMed).
: "Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome." dans: Journal of the American Society of Nephrology : JASN, Vol. 17, Issue 7, pp. 2017-25, (2006) (PubMed).
: "Monoclonal antibody detection of CD46 clustering beneath Neisseria gonorrhoeae microcolonies." dans: Infection and immunity, Vol. 74, Issue 4, pp. 2428-35, (2006) (PubMed).
: "The distal short consensus repeats 1 and 2 of the membrane cofactor protein CD46 and their distance from the cell membrane determine productive entry of species B adenovirus serotype 35." dans: Journal of virology, Vol. 79, Issue 15, pp. 10013-22, (2005) (PubMed).
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Macropinocytotic uptake and infection of human epithelial cells with species B2 adenovirus type 35." dans: Journal of virology, Vol. 84, Issue 10, pp. 5336-50, (2010) (PubMed).
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- Antigène
- CD46
- Autre désignation
- CD46 (CD46 Produits)
- Sujet
- CD46 Molecule,CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.,MCP, TLX, AHUS2, MIC10, MGC26544
- ID gène
- 4179
- UniProt
- P15529
- Pathways
- Regulation of Actin Filament Polymerization
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