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CD7 anticorps

Name: CD7 anticorps
Brand: antibodies-online
SKU: ABIN94218
Price: 300.56 EUR
Availability: InStock

CD7 Reactivité: Humain FACS, WB, IP, IHC (p) Hôte: Souris Monoclonal MEM-186 unconjugated

Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD7 (MEM-186) purified antibody (concentration in sample 0,33 μg/mL, GAM APC). (CD7 anticorps)

FACS

Surface staining of human peripheral blood cells with anti-human CD7 (MEM-186) FITC. (CD7 anticorps)

FACS

Separation of human CD7 positive lymphocytes (red-filled) from neutrophil granulocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD7 (MEM-186) purified antibody (concentration in sample 0,33 μg/mL, GAM APC). (CD7 anticorps)

FACS

3 images

(1 reference)

N° du produit ABIN94218

Fiche de données

Antigène Voir toutes CD7 Anticorps

CD7
Reactivité
196

24

10

10

6
Humain
Hôte
111

85

1

1
Souris
Anticorps secondaires appropriés
Clonalité
115

82

1
Monoclonal
Conjugué
69

21

16

15

12

8

4

4

3

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Cet anticorp CD7 est non-conjugé
Application
117

67

52

30

27

17

14

12

7

6

3

2

1

1

1

1

1

1

1

1
Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité

The antibody MEM-186 reacts with an extracellular epitope of CD7, a 40 kD type I transmembrane glycoprotein expressed on peripheral blood T lymphocytes, NK-cells, hematopoietic progenitors, monocytes (weakly) and also on acute lymphocytic leukemia.

Réactivité croisée (Details)

Human

Purification

Purified by protein-A affinity chromatography.

Pureté

> 95 % (by SDS-PAGE)

Immunogène

Human acute myelogenous leukaemia cell line KG-1.

Clone

MEM-186

Isotype

IgG1

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GMP Grade CD7 Reactivité: Humain FACS Hôte: Souris Monoclonal 4H9 unconjugated

Indications d'application

Immunohistochemistry (paraffin sections): Recommended dilution: 5 μg/mL, positive tissue: spleen.
Flow cytometry: Recommended dilution: 2 μg/mL.
Western blotting: Non-reducing conditions.

Restrictions

For Research Use only
Concentration

1 mg/mL

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur

Sodium azide

Précaution d'utilisation

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation

Do not freeze.

Stock

4 °C

Stockage commentaire

Store at 2-8°C. Do not freeze.
Rappl, Riet, Awerkiew, Schmidt, Hombach, Pfister, Abken: "The CD3-zeta chimeric antigen receptor overcomes TCR Hypo-responsiveness of human terminal late-stage T cells." dans: PLoS ONE, Vol. 7, Issue 1, pp. e30713, (2012) (PubMed).
Antigène

CD7

Autre désignation

CD7 (CD7 Produits)

Synonymes

anticorps GP40, anticorps LEU-9, anticorps TP41, anticorps Tp40, anticorps CD7 molecule, anticorps CD7 antigen, anticorps Cd7 molecule, anticorps CD7, anticorps Cd7

Sujet

CD7 Molecule,CD7, also known as gp40, is a member of the immunoglobulin superfamily found on T cells, NK cells, thymocytes, hematopoietic progenitors, and monocytes (weakly). CD7 is also expressed on acute lymphocytic leukemia (ALL). CD7 crosslinking induces a calcium flux in T lymphocytes, presumably as a result of cytoplasmic domain association with PI3-kinase. CD7 co-stimulation can induce cytokine secretion and modulate cellular adhesion. A ligand of CD7, epithelial cell secreted protein K12, is produced in thymus to regulate thymocyte signaling and cytokine release. In lung microvascular endothelial cells CD7 serves as an IgM Fc receptor. Expression of CD7 is an important marker used in leukemia diagnostics.,GP40, TLA, TP41, LEU-9

ID gène

924

UniProt

P09564

Pathways

Cell-Cell Junction Organization