CD72 anticorps
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- Antigène Voir toutes CD72 Anticorps
- CD72 (CD72 Molecule (CD72))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CD72 est non-conjugé
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Application
- Flow Cytometry (FACS), Immunoprecipitation (IP)
- Specificité
- The mouse monoclonal antibody 3F3 recognizes an extracellular epitope of CD72, a 39-43 kDa type II membrane glycoprotein (C-type lectin family). CD72 is a pan-B cell marker expressed throughout the B lymphocytes diferentiation with the exception of plasma cells, it is also present on follicular dendritic cells.
- Réactivité croisée (Details)
- Human
- Purification
- Purified by protein-A affinity chromatography.
- Pureté
- > 95 % (by SDS-PAGE)
- Immunogène
- Normal human lymphocytes from a lymph node.
- Clone
- 3F3
- Isotype
- IgG2b
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- Indications d'application
- Flow cytometry: Recommended dilution: 1 μg/mL.
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Agent conservateur
- Sodium azide
- Conseil sur la manipulation
- Do not freeze.
- Stock
- 4 °C
- Stockage commentaire
- Store at 2-8°C. Do not freeze.
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CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72." dans: PLoS ONE, Vol. 2, Issue 9, pp. e818, (2007) (PubMed).
: "
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CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72." dans: PLoS ONE, Vol. 2, Issue 9, pp. e818, (2007) (PubMed).
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- Antigène
- CD72 (CD72 Molecule (CD72))
- Autre désignation
- CD72 (CD72 Produits)
- Synonymes
- anticorps CD72c, anticorps Ly-19, anticorps Ly-32, anticorps Ly-m19, anticorps Lyb-2, anticorps CD72b, anticorps LYB2, anticorps CD72 antigen, anticorps CD72 molecule, anticorps Cd72, anticorps CD72
- Sujet
- CD72 Molecule,CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.,LYB2
- ID gène
- 971
- UniProt
- P21854
- Pathways
- BCR Signaling
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