AKR1C3 anticorps (Middle Region)

N° du produit ABIN950321

Détail du produit anti-AKR1C3 anticorps

Antigène: AKR1C3 (Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3))

Épitope: AA 114-143, Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AKR1C3 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to AKR1C3.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogène: KLH conjugated synthetic peptide between 114-143 amino acids from the Central region of human AKR1C3

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) sodium azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur AKR1C3

Antigène: AKR1C3 (Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3))

Abstract: AKR1C3 Produits

Synonymes: anticorps AKR1C3, anticorps PGFS, anticorps MGC134333, anticorps DD3, anticorps DDX, anticorps HA1753, anticorps HAKRB, anticorps HAKRe, anticorps HSD17B5, anticorps hluPGFS, anticorps Akr1c18, anticorps aldo-keto reductase family 1, member C3 L homeolog, anticorps aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II), anticorps aldo-keto reductase family 1 member C2, anticorps aldo-keto reductase family 1 member C3, anticorps aldo-keto reductase family 1, member C3, anticorps akr1c3.L, anticorps AKR1C3, anticorps LOC722496, anticorps Akr1c3

Sujet: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.Synonyms: 17-beta-hydroxysteroid dehydrogenase type 5, 2-dihydrobenzene-1, 2-diol dehydrogenase, 3-alpha-HSD type II, 3-alpha-HSD type II, 3-alpha-hydroxysteroid dehydrogenase type 2, Aldo-keto reductase family 1 member C3, Chlordecone reductase homolog HAKRb, Dihydrodiol dehydrogenase 3, Dihydrodiol dehydrogenase type I, HA1753, HSD17B5, KIAA0119, PGFS, Prostaglandin F synthase, Testosterone 17-beta-dehydrogenase 5, Trans-1, brain

ID gène: 8644

NCBI Accession: NP_003730

Pathways: Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Biosynthesis, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, C21-Steroid Hormone Metabolic Process, Protein targeting to Nucleus