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CTLA4 anticorps (N-Term)
CTLA4
Reactivité: Humain
WB, IHC (p), EIA
Hôte: Lapin
Polyclonal
unconjugated
Détail du produit anti-CTLA4 anticorps
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Antigène
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CTLA4
(Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
Épitope
Tous les épitopes à travers CTLA4 Anticorps.
AA 57-86, N-Term
Reactivité
Toutes les réactivités sur CTLA4 Anticorps
Humain
Hôte
Toutes les hôtes sur CTLA4 Anticorps
Lapin
Clonalité
Toutes les clonalités sur CTLA4 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers CTLA4 Anticorps
Cet anticorp CTLA4 est non-conjugé
Application
Tous les applications à travers CTLA4 Anticorps.
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
Specificité
This antibody recognizes Human CD152 / CTLA4 (N-term).
Purification
Affinity Chromatography on Protein A
Immunogène
KLH conjugated synthetic peptide between 57-86 amino acids from the N-terminal region of Human CD152 / CTLA4. Genename: CTLA4
Isotype
Ig Fraction
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Discover our top product CTLA4 Anticorps primaire
Alternatives
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Information d'application
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Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Stockage
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Format
Liquid
Concentration
0.25 mg/mL
Buffer
PBS, 0.09 % Sodium Azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Références pour anticorps anti-CTLA4 (ABIN951196)
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Karpathiou, Chauleur, Hathroubi, Habougit, Peoch : "Expression of CD3, PD-L1 and CTLA-4 in mammary and extra-mammary Paget disease. " dans: Cancer immunology, immunotherapy : CII , Vol. 67 , Issue 8 , pp. 1297-1303 , (2018 ) (PubMed ).
Karpathiou, Casteillo, Giroult, Forest, Fournel, Monaya, Froudarakis, Dumollard, Prades, Peoch : "Prognostic impact of immune microenvironment in laryngeal and pharyngeal squamous cell carcinoma: Immune cell subtypes, immuno-suppressive pathways and clinicopathologic characteristics. " dans: Oncotarget , Vol. 8 , Issue 12 , pp. 19310-19322 , (2017 ) (PubMed ).
Détails sur CTLA4
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Antigène
CTLA4
(Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
Autre désignation
CD152 / CTLA4 (CTLA4 Produits )
Synonymes
anticorps CTLA-4, anticorps CTLA4, anticorps CD152, anticorps Cd152, anticorps Ctla-4, anticorps Ly-56, anticorps CD, anticorps CELIAC3, anticorps GRD4, anticorps GSE, anticorps IDDM12, anticorps sCTLA4, anticorps cytotoxic T-lymphocyte associated protein 4, anticorps cytotoxic T-lymphocyte-associated protein 4, anticorps CTLA4, anticorps Ctla4
Sujet
CTLA4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.Synonyms: CTLA-4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4
Poids moléculaire
24656 Da
ID gène
1493
NCBI Accession
NP_001032720
Pathways
Cancer Immune Checkpoints
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