PD-1 anticorps
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- Antigène Voir toutes PD-1 (PDCD1) Anticorps
- PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
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Reactivité
- Souris
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Hôte
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Hamster
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp PD-1 est non-conjugé
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Application
- Flow Cytometry (FACS)
- Specificité
- This Monoclonal Antibody reacts with Mouse PD-1 (Programmed Death-1).
- Purification
- Protein G Chromatography
- Immunogène
- PD-1 cDNA transfectant. Donor: mouse ascites fluid. Fusion Partner: Mouse myeloma P3U1.
- Clone
- J43
- Isotype
- IgG
- Top Product
- Discover our top product PDCD1 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS containing 0.02 % Sodium Azide as preservative
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
- Autre désignation
- CD279 / PD1 (PDCD1 Produits)
- Synonymes
- anticorps CD279, anticorps PD-1, anticorps PD1, anticorps SLEB2, anticorps hPD-1, anticorps hPD-l, anticorps Ly101, anticorps Pdc1, anticorps programmed cell death 1, anticorps PDCD1, anticorps Pdcd1
- Sujet
- CD279 is 50-55kD membrane protein which is a member of the CD28 family, and functions mainly as a negative regulator of T-cell activation. CD279 has two specific ligands, CD274 (PD-L1) and CD273 (PD-L2), and their interaction is key in the balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and self-tolerance. CD279 is inducibly expressed by T-cells, B-cells, NK-T-cells and monocytes upon activation. Loss of CD279 function has been associated with a number of autoimmune diseases, including rheumatoid arthritis, type I diabetes and ankylosing spondylitis. Recent studies suggest that CD279 could be targeted therapeutically in the treatment of HIV infection to reduce T-cell exhaustion.Synonyms: PDCD1, Programmed cell death protein 1, Protein PD-1, hPD-1
- ID gène
- 18566
- NCBI Accession
- NP_032824
- UniProt
- Q02242
- Pathways
- Cancer Immune Checkpoints
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