FBXW7 anticorps (AA 599-708)

N° du produit ABIN952295

Détail du produit anti-FBXW7 anticorps

Antigène: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Épitope: AA 599-708

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FBXW7 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: Recognizes Fbxw7

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Protein A Chromatography

Immunogène: FBXW7 (NP_361014, 599 a.a. ~ 708 a.a) partial recombinant protein with GST tag.

Clone: 3D1

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS, pH 7.2

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur FBXW7

Antigène: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Autre désignation: FBXW7 (FBXW7 Produits)

Synonymes: anticorps cdc4, anticorps AGO, anticorps CDC4, anticorps FBW6, anticorps FBW7, anticorps FBX30, anticorps FBXO30, anticorps FBXW6, anticorps SEL-10, anticorps SEL10, anticorps hAgo, anticorps hCdc4, anticorps 1110001A17Rik, anticorps Cdc4, anticorps Fbw7, anticorps Fbwd6, anticorps Fbx30, anticorps Fbxo30, anticorps Fbxw6, anticorps F-box and WD repeat domain containing 7, anticorps F-box and WD-40 domain protein 7, anticorps Fbxw7, anticorps FBXW7, anticorps fbxw7

Sujet: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.Synonyms: Archipelago homolog, F-box and WD-40 domain-containing protein 7, F-box protein FBX30, F-box/WD repeat-containing protein 7, FBW7, FBX30, SEL-10, SEL10, hAgo, hCDC4

ID gène: 55294

NCBI Accession: NP_001013433

UniProt: Q969H0

Pathways: Signalisation Notch, EGFR Signaling Pathway