anticorps MRGX2, anticorps G370024M05Rik, anticorps MrgB10, anticorps Mrgprb10, anticorps MrgB1, anticorps Mrgprb1, anticorps MAS related GPR family member X2, anticorps MAS-related GPR, member X2, anticorps MRGPRX2, anticorps Mrgprx2
Sujet
MRGPRX2 is the orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.Synonyms: MRGX2, Mas-related G-protein coupled receptor member X2