anticorps D13Wsu123e, anticorps Misu, anticorps MISU, anticorps MRT5, anticorps SAKI, anticorps TRM4, anticorps RGD1311954, anticorps NOL1/NOP2/Sun domain family member 2, anticorps NOP2/Sun RNA methyltransferase family member 2, anticorps NOP2/Sun RNA methyltransferase family, member 2, anticorps NOP2/Sun RNA methyltransferase family member 2 S homeolog, anticorps Nsun2, anticorps NSUN2, anticorps nsun2.S
Sujet
Maturation of cytoplasmic tRNAs includes splicing of introns, which are located 1 nucleotide 3-prime from the anticodon in all intron-containing tRNA genes. In tRNA-leu(CAA), the first position of the anticodon, C34, is converted to 5-methylcytosine, a modification necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. NSUN2 encodes a methyltransferase that catalyzes the intron-dependent formation of 5-methylcytosine at C34 of tRNA-leu(CAA) (Brzezicha et al., 2006 [PubMed 17071714])Synonyms: NOL1/NOP2/Sun domain family member 2, SAKI, Substrate of AIM1/Aurora kinase B, TRM4, tRNA (cytosine-5-)-methyltransferase, tRNA (cytosine-5-)-methyltransferase NSUN2, tRNA methyltransferase 4 homolog