Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Format
Liquid
Concentration
0.25 mg/mL
Buffer
PBS with 0.09 % (W/V) sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
Feenstra, Thøgersen, Wieser, Peschel, Ball, Brandes, Satchell, Stockner, Aarestrup, Rees, Kain: "Adhesion of Escherichia coli under flow conditions reveals potential novel effects of FimH mutations." dans: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, Vol. 36, Issue 3, pp. 467-478, (2017) (PubMed).
The protein is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.Synonyms: TSPAN21, Tetraspanin-21, Tspan-21, UP1a, UPIa, UPKa, Uroplakin Ia