USP7 anticorps (Middle Region)
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- Antigène Voir toutes USP7 Anticorps
- USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
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Épitope
- AA 319-348, Middle Region
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp USP7 est non-conjugé
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Specificité
- This antibody detects USP7 / HAUSP (Center).
- Réactivité croisée (Details)
- Species reactivity (tested):Human
- Purification
- Protein A column followed by peptide affinity purification
- Immunogène
- KLH conjugated synthetic peptide between 319-348 amino acids from the Central region of human USP7
- Isotype
- Ig Fraction
- Top Product
- Discover our top product USP7 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.25 mg/mL
- Buffer
- PBS with 0.09 % (W/V) sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
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- Antigène
- USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
- Autre désignation
- USP7 / HAUSP (USP7 Produits)
- Synonymes
- anticorps CG1490, anticorps Dmel\\CG1490, anticorps USP7, anticorps 2210010O09Rik, anticorps AA409944, anticorps AA617399, anticorps AU019296, anticorps AW548146, anticorps C80752, anticorps Hausp, anticorps HAUSP, anticorps TEF1, anticorps UBP, anticorps Ubiquitin-specific protease 7, anticorps ubiquitin carboxyl-terminal hydrolase 7, anticorps ubiquitin specific peptidase 7, anticorps Usp7, anticorps LOC100201254, anticorps USP7
- Sujet
- Hydrolase that deubiquitinates target proteins such as FOXO4, TP53, MDM2, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and proteasomal degradation. Deubiquitinates TP53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2, and also induces TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection.Synonyms: Deubiquitinating enzyme 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin carboxyl-terminal hydrolase 7, Ubiquitin thioesterase 7, Ubiquitin-specific-processing protease 7
- ID gène
- 7874
- NCBI Accession
- NP_003461
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