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WDR48 anticorps (C-Term)

WDR48 Reactivité: Humain WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN955556
  • Antigène Voir toutes WDR48 Anticorps
    WDR48 (WD Repeat Domain 48 (WDR48))
    Épitope
    • 10
    • 10
    • 6
    • 1
    AA 610-638, C-Term
    Reactivité
    • 20
    • 4
    • 3
    Humain
    Hôte
    • 21
    Lapin
    Clonalité
    • 21
    Polyclonal
    Conjugué
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp WDR48 est non-conjugé
    Application
    • 19
    • 17
    • 15
    • 13
    • 3
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects WDR48 / p80 (C-term).
    Réactivité croisée (Details)
    Species reactivity (tested):Human
    Purification
    Protein A column followed by peptide affinity purification
    Immunogène
    KLH conjugated synthetic peptide between 610-638 amino acids from the C-terminal region of human WDR48
    Isotype
    Ig Fraction
    Top Product
    Discover our top product WDR48 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
  • Antigène
    WDR48 (WD Repeat Domain 48 (WDR48))
    Autre désignation
    WDR48 / p80 (WDR48 Produits)
    Synonymes
    anticorps P80, anticorps UAF1, anticorps 8430408H12Rik, anticorps mKIAA1449, anticorps WD repeat domain 48, anticorps WDR48, anticorps Wdr48
    Sujet
    Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2, USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1.Synonyms: KIAA1449, UAF1, USP1-associated factor 1, WD repeat endosomal protein, WD repeat-containing protein 48
    ID gène
    57599
    NCBI Accession
    NP_065890
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