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PYM anticorps (N-Term)

WIBG Reactivité: Humain, Souris WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN955577
  • Antigène Voir toutes PYM (WIBG) Anticorps
    PYM (WIBG) (Partner of Y14 and mago (WIBG))
    Épitope
    • 8
    • 7
    • 6
    • 2
    • 1
    • 1
    AA 15-44, N-Term
    Reactivité
    • 29
    • 18
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 27
    • 2
    Lapin
    Clonalité
    • 27
    • 2
    Polyclonal
    Conjugué
    • 12
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PYM est non-conjugé
    Application
    • 21
    • 15
    • 13
    • 4
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects WIBG / PYM (N-term).
    Réactivité croisée (Details)
    Species reactivity (tested):Human, mouse
    Purification
    Protein A column followed by peptide affinity purification
    Immunogène
    KLH conjugated synthetic peptide between 15-44 amino acids from the N-terminal region of human WIBG
    Isotype
    Ig Fraction
    Top Product
    Discover our top product WIBG Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
  • Antigène
    PYM (WIBG) (Partner of Y14 and mago (WIBG))
    Autre désignation
    WIBG / PYM (WIBG Produits)
    Synonymes
    anticorps BEST:HL05757, anticorps CG10330, anticorps CG30176, anticorps Dmel\\CG30176, anticorps PYM, anticorps Pym, anticorps UD3, anticorps A030010B05Rik, anticorps zgc:65891, anticorps zgc:77281, anticorps Partner of Y14 and Mago, anticorps Wibg protein, anticorps PYM homolog 1, exon junction complex associated factor L homeolog, anticorps PYM homolog 1, exon junction complex associated factor, anticorps Pym, anticorps wibg, anticorps pym1.L, anticorps PYM1, anticorps Pym1, anticorps pym1
    Sujet
    Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA, the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.Synonyms: Partner of Y14 and mago, Protein wibg homolog
    ID gène
    84305
    NCBI Accession
    NP_001137325
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