UBASH3B anticorps (C-Term)

N° du produit ABIN964881

Détail du produit anti-UBASH3B anticorps

Antigène: UBASH3B (STS1) (Cbl-Interacting Protein Sts-1 (STS1))

Épitope: C-Term

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UBASH3B est non-conjugé

Application: Western Blotting (WB), ELISA

Attributs du produit: Concentration Definition: by UV absorbance at 280 nm

Stérilité: Sterile filtered

Immunogène: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the of mouse Sts-1.

Isotype: IgG

Information d'application

Indications d'application: This affinity purified antibody has been tested for use in ELISA and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.63 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-UBASH3B (ABIN964881)

Carpino, Turner, Mekala, Takahashi, Zang, Geiger, Doherty, Ihle: "Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2." dans: Immunity, Vol. 20, Issue 1, pp. 37-46, (2004) (PubMed).

Carpino, Kobayashi, Zang, Takahashi, Jou, Feng, Nakajima, Ihle: "Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein." dans: Molecular and cellular biology, Vol. 22, Issue 21, pp. 7491-500, (2002) (PubMed).

Détails sur UBASH3B

Antigène: UBASH3B (STS1) (Cbl-Interacting Protein Sts-1 (STS1))

Autre désignation: Sts-1 (STS1 Produits)

Synonymes: anticorps STS-1, anticorps STS1, anticorps TULA-2, anticorps p70, anticorps 2810457I06Rik, anticorps BB125008, anticorps RGD1310357, anticorps Sts-1, anticorps ubiquitin associated and SH3 domain containing B, anticorps ubiquitin associated and SH3 domain containing, B, anticorps UBASH3B, anticorps Ubash3b

Sujet: Sts-1 is a protein that inhibits endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.  Sts-1 and Sts-2 (formerly p70 and Clip4, respectively) have been found to interact with Cbl, an ubiquitin ligase that plays a critical role in attenuation of receptor tyrosine kinase signaling by inducing ubiquitination and promoting their sorting for endosomal degradation.  Sts-1 and Sts-2 contain SH3 domains that interact with Cbl, Ub-associated domains, which bind directly to mono-Ub or to the EGFR/Ub chimera, as well as phosphoglycerate mutase domains that mediate oligomerization of Sts-1/2.   Sts-1 and Sts-2 also have been found to negatively regulate signaling pathways that control T cell receptors, which in turn affect the extent and duration of the T cell response to foreign pathogens.
Synonyms: Cbl interacting protein p70 antibody, Cbl interacting protein Sts 1 antibody, Nm23 phosphorylated unknown substrate antibody, p70 antibody, SH3 domain containing 70 kDa protein antibody

ID gène: 84959, 24497612

UniProt: Q8TF42