Purified by antigen-specific affinity chromatography.
Immunogène
Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human ARL1(ADP-ribosylation factor-like protein 1)
ARL1
Reactivité: Humain
Hôte: Lapin
Polyclonal
FITC
Indications d'application
ELISA, Western blotting: 1µg/ml for 2hrs.
Restrictions
For Research Use only
Format
Liquid
Buffer
This antibody is stored in PBS, 50% glycerol
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
-20 °C
Van Valkenburgh, Shern, Sharer, Zhu, Kahn: "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins." dans: The Journal of biological chemistry, Vol. 276, Issue 25, pp. 22826-37, (2001) (PubMed).
Hong, Lee, Patton, Lin, Moss, Vaughan: "Phospholipid- and GTP-dependent activation of cholera toxin and phospholipase D by human ADP-ribosylation factor-like protein 1 (HARL1)." dans: The Journal of biological chemistry, Vol. 273, Issue 25, pp. 15872-6, (1998) (PubMed).
Antigène
ARL1
(ADP Ribosylation Factor Like GTPase 1 (ARL1))
ARL1(ADP-ribosylation factor-like protein 1) belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Recent data show that Arl1 regulates the membrane recruitment of Golgin-97, which plays a role in transport from the endosome to the trans-Golgi network.