Ataxin 10 anticorps (C-Term)

N° du produit ABIN965623

Détail du produit anti-Ataxin 10 anticorps

Antigène: Ataxin 10 (ATXN10)

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ataxin 10 est non-conjugé

Application: Immunohistochemistry (IHC)

Purification: Purified by antigen-specific affinity chromatography.

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ATXN10(Ataxin-10)

Information d'application

Indications d'application: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-Ataxin 10 (ABIN965623)

Matsuura, Fang, Pearson, Jayakar, Ashizawa, Roa, Nelson: "Interruptions in the expanded ATTCT repeat of spinocerebellar ataxia type 10: repeat purity as a disease modifier?" dans: American journal of human genetics, Vol. 78, Issue 1, pp. 125-9, (2005) (PubMed).

Wiemann, Weil, Wellenreuther, Gassenhuber, Glassl, Ansorge, Böcher, Blöcker, Bauersachs, Blum, Lauber, Düsterhöft, Beyer, Köhrer, Strack, Mewes, Ottenwälder, Obermaier, Tampe, Heubner, Wambutt, Korn et al.: "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. ..." dans: Genome research, Vol. 11, Issue 3, pp. 422-35, (2001) (PubMed).

Matsuura, Yamagata, Burgess, Rasmussen, Grewal, Watase, Khajavi, McCall, Davis, Zu, Achari, Pulst, Alonso, Noebels, Nelson, Zoghbi, Ashizawa: "Large expansion of the ATTCT pentanucleotide repeat in spinocerebellar ataxia type 10." dans: Nature genetics, Vol. 26, Issue 2, pp. 191-4, (2000) (PubMed).

Détails sur Ataxin 10

Antigène: Ataxin 10 (ATXN10)

Autre désignation: ATXN10 (ATXN10 Produits)

Synonymes: anticorps ATXN10, anticorps MGC97716, anticorps atxn10, anticorps Ataxin-10, anticorps si:dkeyp-15g12.2, anticorps E46L, anticorps HUMEEP, anticorps SCA10, anticorps Sca10, anticorps AI325283, anticorps C77170, anticorps E46, anticorps TEG-169, anticorps Tex169, anticorps ataxin 10, anticorps ATXN10, anticorps atxn10, anticorps Atxn10

Sujet: The autosomal dominant cerebellar ataxias (ADCAs) are a clinically and genetically heterogeneous group of disorders characterized by ataxia, dysarthria, dysmetria, and intention tremor. All ADCAs involve some degree of cerebellar dysfunction and a varying degree of signs from other components of the nervous system. Defects in ATXN10 are the cause of spinocerebellar ataxia type 10. SCA10 is an autosomal dominant disorder and is predominantly characterized by cerebellar ataxia seizures. In addition patients often show soft pyramidal signs, ocular dyskinesia, cognitive impairment, and/or behavioral disturbances. SCA10 has been recognized only in families of Mexican origin. The molecular basis of the disease is due to an ATTCT nucleotide repeat expansion in intron 9.