AURKB
Reactivité: Humain, Souris, Rat, Boeuf (Vache), Porc
WB, IHC, IHC (p)
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Western Blot: 1: 500- 1: 2,000 ELISA: Propose dilution 1: 10,000. Determining optimal working dilutions by titration test.
Restrictions
For Research Use only
Format
Liquid
Stock
-20 °C
Song, So, Cheng, Tang, Croft: "Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion." dans: Immunity, Vol. 22, Issue 5, pp. 621-31, (2005) (PubMed).
Kapoor, Lavoie, Frappier: "EBP2 plays a key role in Epstein-Barr virus mitotic segregation and is regulated by aurora family kinases." dans: Molecular and cellular biology, Vol. 25, Issue 12, pp. 4934-45, (2005) (PubMed).
AURKB (aurora kinase B, AIK2 or aurora-B), with 344amino acid protein(about 39kDa),localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AURKB is a mitotic protein kinase, which phosphorylates histone H3 and regulates Chromosomal segregation during mitosis and meiosis. It may regulates several stages of mitosis such as centrosome separation, chromosome segregation and cytokinesis.Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. ARK-2 transcripts arepresent at high levels in human thymus and fetal liver.ARK-2 protein levels are maximal during both S and G2/M phases