Dilution ELISA: Propose dilution 1: 10,000 Determining optimal working dilutions by titration test.
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Mojica, Saxena, Starostik, Cheney: "CD117+ small cell lung cancer lacks the asp 816-->val point mutation in exon 17." dans: Histopathology, Vol. 47, Issue 5, pp. 517-22, (2005) (PubMed).
Tong, Liu, Zhang, Xiong, Liu, Zhang: "Expression of c-kit messenger ribonucleic acid and c-kit protein in sigmoid colon of patients with slow transit constipation." dans: International journal of colorectal disease, Vol. 20, Issue 4, pp. 363-7, (2005) (PubMed).
Nakai, Nonomura, Oka, Shiba, Arai, Nakayama, Inoue, Nishimura, Aozasa, Mizutani, Miki, Okuyama: "KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors." dans: Biochemical and biophysical research communications, Vol. 337, Issue 1, pp. 289-96, (2005) (PubMed).
C-kit (CD117,145kDa) functions as a tyrosine kinase receptor which becomes activated upon binding of its ligand SCF (stem-cell factor), the C-kit gene encodes the human homolog of the proto-oncogene ckit. which was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT is a type 3 transmembrane receptor for MGF (mast cell growth factor). Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism.