KRT17 anticorps
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- Antigène Voir toutes KRT17 Anticorps
- KRT17 (Keratin 17 (KRT17))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp KRT17 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Purification
- Ascitic fluid
- Immunogène
- Purified recombinant fragment of CK17 expressed in E. Coli.
- Clone
- 3B12
- Isotype
- IgG2b
- Top Product
- Discover our top product KRT17 Anticorps primaire
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- Indications d'application
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Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test. - Restrictions
- For Research Use only
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- Format
- Liquid
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
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Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome." dans: The American journal of pathology, Vol. 161, Issue 6, pp. 1991-6, (2002) (PubMed).
: "Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro." dans: The British journal of dermatology, Vol. 133, Issue 4, pp. 501-11, (1995) (PubMed).
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Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome." dans: The American journal of pathology, Vol. 161, Issue 6, pp. 1991-6, (2002) (PubMed).
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- Antigène
- KRT17 (Keratin 17 (KRT17))
- Autre désignation
- CK17 (KRT17 Produits)
- Synonymes
- anticorps K17, anticorps Krt1-17, anticorps PC, anticorps PC2, anticorps PCHC1, anticorps Ka17, anticorps KRT17, anticorps krt16, anticorps si:dkeyp-113d7.7, anticorps KRT14, anticorps keratin 17, anticorps keratin 17 L homeolog, anticorps keratin 17, type I, anticorps keratin, type I cytoskeletal 17, anticorps Krt17, anticorps KRT17, anticorps krt17, anticorps krt17.L, anticorps LOC100737113, anticorps LOC102177275
- Sujet
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CK17, also known as KRT17, it is the type I intermediate filament chain keratin 17. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
Synonyms: PC, K17, PC2, PCHC1, KRT17 - Poids moléculaire
- 49kDa
- ID gène
- 3872
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