CLOCK anticorps (N-Term)

N° du produit ABIN965906

Détail du produit anti-CLOCK anticorps

Antigène: CLOCK (Clock Homolog (Mouse) (CLOCK))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CLOCK est non-conjugé

Application: Immunohistochemistry (IHC)

Purification: Purified by antigen-specific affinity chromatography.

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human CLOCK(Circadian locomoter output cycles protein kaput)

Information d'application

Indications d'application: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-CLOCK (ABIN965906)

Moreira, Pedrazzoli, Dos Santos Coelho, Pradella-Hallinan, Lopes da Conceição, Pereira Peregrino, de Oliveira, Tufik: "Clock gene polymorphisms and narcolepsy in positive and negative HLA-DQB1*0602 patients." dans: Brain research. Molecular brain research, Vol. 140, Issue 1-2, pp. 150-4, (2005) (PubMed).

Détails sur CLOCK

Antigène: CLOCK (Clock Homolog (Mouse) (CLOCK))

Autre désignation: CLOCK (CLOCK Produits)

Synonymes: anticorps CG7391, anticorps CLK, anticorps CLOCK, anticorps Dmel\\CG7391, anticorps Jerk, anticorps Jrk, anticorps PAS1, anticorps bHLHe10, anticorps clk, anticorps clock, anticorps dCLK, anticorps dCLK/JRK, anticorps dCLOCK, anticorps dClck, anticorps dClk, anticorps dClock, anticorps dclk, anticorps jrk, anticorps Xclk, anticorps XClock, anticorps zCLOCK1, anticorps zfCLOCK1, anticorps 5330400M04Rik, anticorps KAT13D, anticorps bHLHe8, anticorps mKIAA0334, anticorps Clock, anticorps clock circadian regulator, anticorps clock homolog (mouse), anticorps clock circadian regulator a, anticorps circadian locomotor output cycles kaput, anticorps clock circadian regulator L homeolog, anticorps Clk, anticorps CLOCK, anticorps clock, anticorps clocka, anticorps Clock, anticorps clock.L

Sujet: CLOCK(Circadian locomoter output cycles protein kaput) is a circadian regulator that acts as a transcription factor. CLOCK-BMAL1 heterodimers bind to an E-box element (3'-CACGTG-5'), thereby activating transcription of PER1, and possibly of other circadian clock proteins. Mutant CLOCK and BMAL1 form hetereodimers that bind DNA, but fail to activate transcription. CLOCK belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1.

Pathways: Regulation of Lipid Metabolism by PPARalpha, Photoperiodism