DCK anticorps (N-Term)

N° du produit ABIN965975

Il existe 1 publication pour ce produit. L’anticorps anti-DCK Polyclonal Lapin est utilisé pour la détection de DCK dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour DCK anticorps (N-Term) (ABIN965975)

Antigène: DCK (Deoxycytidine Kinase (DCK))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DCK est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-DCK anticorps

Épitope: N-Term

Purification: Purified by antigen-specific affinity chromatography.

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human DCK (deoxycytidine kinase)

Information d'application

Indications d'application: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-DCK (ABIN965975)

Innoceta, Galluzzi, Ruzzo, Andreoni, Chiarantini, Magnani: "Molecular basis of 2',3'-dideoxycytidine-induced drug resistance in human cells." dans: Molecular and cellular biochemistry, Vol. 231, Issue 1-2, pp. 173-7, (2002) (PubMed).

Détails sur DCK

Antigène: DCK (Deoxycytidine Kinase (DCK))

Autre désignation: DCK

Sujet: Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.