EDEM1 anticorps (C-Term)

N° du produit ABIN966027

Détail du produit anti-EDEM1 anticorps

Antigène: EDEM1 (ER Degradation Enhancer, Mannosidase alpha-Like 1 (EDEM1))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EDEM1 est non-conjugé

Application: Immunohistochemistry (IHC)

Purification: Purified by antigen-specific affinity chromatography.

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human EDEM1(ER degradation-enhancing alpha-mannosidase-like 1)

Information d'application

Indications d'application: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-EDEM1 (ABIN966027)

Molinari, Calanca, Galli, Lucca, Paganetti: "Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle." dans: Science (New York, N.Y.), Vol. 299, Issue 5611, pp. 1397-400, (2003) (PubMed).

Nagase, Seki, Ishikawa, Ohira, Kawarabayasi, Ohara, Tanaka, Kotani, Miyajima, Nomura: "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." dans: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 3, Issue 5, pp. 321-9, 341-54, (1997) (PubMed).

Détails sur EDEM1

Antigène: EDEM1 (ER Degradation Enhancer, Mannosidase alpha-Like 1 (EDEM1))

Autre désignation: EDEM1 (EDEM1 Produits)

Sujet: EDEM1(ER degradation-enhancing alpha-mannosidase-like 1) extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. It lacks mannosidase activity. EDEM1 is located in endoplasmic reticulum membrane and is a single-pass type II membrane protein. EDEM1 belongs to the glycosyl hydrolase 47 family.

Pathways: ER-Nucleus Signaling