GPC1 anticorps (C-Term)

N° du produit ABIN966218

Détail du produit anti-GPC1 anticorps

Antigène: GPC1 (Glypican 1 (GPC1))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GPC1 est non-conjugé

Application: Immunohistochemistry (IHC)

Purification: Purified by antigen-specific affinity chromatography.

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human GPC1(Glypican-1 precursor)

Information d'application

Indications d'application: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-GPC1 (ABIN966218)

Davies, Blackhall, Shanks, David, McGown, Swindell, Slade, Martin-Hirsch, Gallagher, Jayson: "Distribution and clinical significance of heparan sulfate proteoglycans in ovarian cancer." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 10, Issue 15, pp. 5178-86, (2004) (PubMed).

Détails sur GPC1

Antigène: GPC1 (Glypican 1 (GPC1))

Autre désignation: GPC1 (GPC1 Produits)

Synonymes: anticorps gpc1, anticorps zgc:63947, anticorps GPC1, anticorps Glypican-1, anticorps glypican, anticorps AI462976, anticorps HSPG M12, anticorps HSPGM12, anticorps glypican 1b, anticorps glypican 1, anticorps gpc1b, anticorps GPC1, anticorps gpc1, anticorps Gpc1

Sujet: GPC1(Glypican-1) is a cell surface proteoglycan that bears heparan sulfate. The protein is attached to the membrane by a GPI-anchor. This cell-associated glypican is further processed to give rise to a medium-released species. The glypican-1 is required for efficient TGF-beta1 signaling in pancreatic cancer cells. The syndecan-1 and glypican-1 have roles in progression of ovarian cancer. Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.

Pathways: Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation