HSV ICP4 anticorps (N-Term)

N° du produit ABIN966334

Détail du produit anti-HSV ICP4 anticorps

Antigène: HSV ICP4 (Herpes Simplex Virus ICP4 (HSV ICP4))

Épitope: N-Term

Reactivité: Herpes Simplex Virus (HSV)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSV ICP4 est non-conjugé

Application: Immunohistochemistry (IHC)

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of Human herpesvirus 2 ICP4 (Trans-acting transcriptional protein ICP4)

Information d'application

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Références pour anticorps anti-HSV ICP4 (ABIN966334)

Dolan, Jamieson, Cunningham, Barnett, McGeoch: "The genome sequence of herpes simplex virus type 2." dans: Journal of virology, Vol. 72, Issue 3, pp. 2010-21, (1998) (PubMed).

Détails sur HSV ICP4

Antigène: HSV ICP4 (Herpes Simplex Virus ICP4 (HSV ICP4))

Abstract: HSV ICP4 Produits

Classe de substances: Viral Protein

Sujet: ICP4 (Trans-acting transcriptional protein ICP4) is a transcriptional transactivator that binds with high affinity to the sequence 5'-ATCGTC-3'. ICP4 may interact with and recruit specific components of the general transcription machinery to viral promoters and stabilize their formation for transcription initiation. ICP4 negatively regulates its own transcription. This immediate early (EI) protein may be necessary in virion for viral pathogenesis. ICP4 is a homodimer and interacts with transcriptional regulator ICP27, this interaction is required for proper incorporation of ICP4 into virions. The long stretch of Ser is a major site of phosphorylation. Only the phosphorylated forms are capable of interacting with beta or gamma genes. ICP4 belongs to the herpesviridae ICP4/IE140/IE180 family.
Synonyms: IE175 (Infected cell protein 4, Transcriptional activator IE175, Alpha-4 protein)