MAPK10 anticorps

N° du produit ABIN966522

Détail du produit anti-MAPK10 anticorps

Antigène: MAPK10 (Mitogen-Activated Protein Kinase 10 (MAPK10))

Reactivité: Humain

Hôte: Veuillez nous consulter SVP

Clonalité: Monoclonal

Conjugué: Cet anticorp MAPK10 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: Ni-NTA purified truncated recombinant MAPK10 expressed in E. Coli strain BL21 (DE3)

Purification: Antibodies are purified by protein A affinity chromatography

Isotype: IgG1

Information d'application

Indications d'application: Western Blot: 1: 500- 1: 1,000
IHC(P): 1: 500- 1: 1,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Stock: -20 °C

Références pour anticorps anti-MAPK10 (ABIN966522)

Irving, Bamford: "Role of mitogen- and stress-activated kinases in ischemic injury." dans: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 22, Issue 6, pp. 631-47, (2002) (PubMed).

Cuenda: "Mitogen-activated protein kinase kinase 4 (MKK4)." dans: The international journal of biochemistry & cell biology, Vol. 32, Issue 6, pp. 581-7, (2000) (PubMed).

Kuan, Yang, Samanta Roy, Davis, Rakic, Flavell: "The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development." dans: Neuron, Vol. 22, Issue 4, pp. 667-76, (1999) (PubMed).

Gupta, Barrett, Whitmarsh, Cavanagh, Sluss, Dérijard, Davis: "Selective interaction of JNK protein kinase isoforms with transcription factors." dans: The EMBO journal, Vol. 15, Issue 11, pp. 2760-70, (1996) (PubMed).

Martin, Mohit, Miller: "Developmental expression in the mouse nervous system of the p493F12 SAP kinase." dans: Brain research. Molecular brain research, Vol. 35, Issue 1-2, pp. 47-57, (1996) (PubMed).

Forsgren, Moravec, Moravec: "Catecholamine-synthesizing enzymes and neuropeptides in rat heart epicardial ganglia; an immunohistochemical study." dans: The Histochemical journal, Vol. 22, Issue 12, pp. 667-76, (1991) (PubMed).

Détails sur MAPK10

Antigène: MAPK10 (Mitogen-Activated Protein Kinase 10 (MAPK10))

Autre désignation: MAPK10 (MAPK10 Produits)

Synonymes: anticorps MAPK10, anticorps zgc:123234, anticorps DKFZp459H0638, anticorps Jnk3, anticorps SAPKC, anticorps SAPb, anticorps Serk2, anticorps JNK3, anticorps JNK3A, anticorps PRKM10, anticorps SAPK1b, anticorps p493F12, anticorps p54bSAPK, anticorps C230008H04Rik, anticorps JNK3B1, anticorps JNK3B2, anticorps SAPK(beta), anticorps ATMPK10, anticorps MAP kinase 10, anticorps mitogen-activated protein kinase 8 S homeolog, anticorps mitogen-activated protein kinase 10, anticorps mitogen activated protein kinase 10, anticorps MAP kinase 10, anticorps mapk8.S, anticorps MAPK10, anticorps mapk10, anticorps Mapk10, anticorps MPK10

Sujet: MAPK10 (mitogen-activated protein kinase 10 ), also called JNK3, which is located on chromosome 4q22.1q23, JNK is an important contributor to stress-induced apoptosis, its isoforms (JNK1, JNK2, and JNK3) have distinct roles in cerebral ischemia. JNK1 is the major isoformresponsible for the high level of basal JNK activity in the brain. In contrast, targeted deletion of Jnk3 not only reduces the stress-induced JNK activity, but also protects mice from brain injury after cerebral ischemiahypoxia. The downstream mechanism of JNK3-mediated apoptosis include the induction of Bim and Fas and the mitochondrial release of cytochrome c. which suggest that JNK3 is a potential target for neuroprotection therapies in stroke. JNK3 is crucial for neuronal apoptosis (stress-induced) and selectively expressed in the nervous system and heart.

ID gène: 5602

Pathways: Signalisation MAPK, Signalisation WNT, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades