Rabbit IgG polyclonal antibody for C-C motif chemokine 2 ( CCL2) detection. Tested with WB in Human, Mouse, Rat.
Immunogène
A synthetic peptide corresponding to a sequence at the N-terminal of human MCP-1, different from the mouse and rat sequence by two amino acids< br/>Immunogen was affinity purified.
At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
Gosling, Slaymaker, Gu, Tseng, Zlot, Young, Rollins, Charo: "MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B." dans: The Journal of clinical investigation, Vol. 103, Issue 6, pp. 773-8, (1999) (PubMed).
Gu, Okada, Clinton, Gerard, Sukhova, Libby, Rollins: "Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice." dans: Molecular cell, Vol. 2, Issue 2, pp. 275-81, (1998) (PubMed).
Furutani, Nomura, Notake, Oyamada, Fukui, Yamada, Larsen, Oppenheim, Matsushima: "Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF)." dans: Biochemical and biophysical research communications, Vol. 159, Issue 1, pp. 249-55, (1989) (PubMed).
Monocyte chemoattractant protein-1 (MCP-1), a member of the chemokine (chemotactic cytokine) family, is a potent monocyte agonist that is upregulated by oxidized lipids. 1 MCP-1 is also known as CCL2, SCYA2, MCAF. MCAF is a member of family of factors involved in immune and inflammatory responses. The amino acid sequence deduced from the nucleotide sequence reveals the primary structure of the MCAF precursor to be composed of a putative signal peptide sequence of 23 amino acid residues and a mature MCAF sequence of 76 amino acid residues. 2 MCP-1 plays a unique and crucial role in the initiation of atherosclerosis and may provide a new therapeutic target in this disorder. 3 Human MCP-1 is a 8. 7KDa non-glycoprotein, consisting of 99 amino acids in precursor form and 76 amino acids in mature form.