MSH2 anticorps
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- Antigène Voir toutes MSH2 Anticorps
- MSH2 (Mismatch Repair Protein 2 (MSH2))
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Reactivité
- Humain
- Hôte
- Veuillez nous consulter SVP
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp MSH2 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Specificité
- Ni-NTA purified recombinant human MSH2 expressed in E. Coli strain BL21 (DE3).
- Purification
- Antibodies are purified by protein G affinity chromatography.
- Isotype
- IgG1
- Top Product
- Discover our top product MSH2 Anticorps primaire
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- Indications d'application
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Western Blot: Dilution 1: 200- 1: 1,000
IHC(P): Dilution 1: 200- 1: 1,000
IHC(F): Dilution 1: 200- 1: 1,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test. - Restrictions
- For Research Use only
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- Stock
- -20 °C
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- Antigène
- MSH2 (Mismatch Repair Protein 2 (MSH2))
- Autre désignation
- MSH2 (MSH2 Produits)
- Synonymes
- anticorps COCA1, anticorps FCC1, anticorps HNPCC, anticorps HNPCC1, anticorps LCFS2, anticorps AI788990, anticorps wu:fc06b02, anticorps wu:fc13e09, anticorps zgc:55333, anticorps ATMSH2, anticorps MUTS homolog 2, anticorps msh2, anticorps mutS homolog 2, anticorps mutS homolog 2 (E. coli), anticorps MUTS homolog 2, anticorps mutS homolog 2 L homeolog, anticorps MutS protein homolog 2, anticorps MSH2, anticorps Msh2, anticorps msh2, anticorps msh2.L
- Sujet
- MSH2 is a 100 kDa nuclear antigen and encodes a protein of 934 amino acids. The MSH2 gene is one of 4 known genes encoding proteins involved in the repair of mismatch nucleotides following DNA replication or repair. Mutations in the MSH2 gene contribute to the development of sporadic colorectal carcinoma. MSHS mutations are responsible for 50% of inherited non-polyposis colorectal (HNPCC). The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process.
- ID gène
- 4436
- Pathways
- Réparation de l'ADN, Production of Molecular Mediator of Immune Response
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