Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human NFKB2 (Nuclear factor NF-kappa-B p100 subunit)
NFKB2
Reactivité: Humain, Souris
ELISA, IHC (p), ICC, FACS, IF (p), IF (cc), IHC (fro)
Hôte: Lapin
Polyclonal
unconjugated
Restrictions
For Research Use only
Stock
4 °C
Li, Nabel: "A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription." dans: Molecular and cellular biology, Vol. 17, Issue 10, pp. 6184-90, (1997) (PubMed).
Dobrzanski, Ryseck, Bravo: "Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity." dans: The EMBO journal, Vol. 13, Issue 19, pp. 4608-16, (1994) (PubMed).
Beg, Baldwin: "Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor." dans: Oncogene, Vol. 9, Issue 5, pp. 1487-92, (1994) (PubMed).
Potter, Larson, Eckes, Schmid, Nabel, Verdine, Sharp: "Purification of the major histocompatibility complex class I transcription factor H2TF1. The full-length product of the nfkb2 gene." dans: The Journal of biological chemistry, Vol. 268, Issue 25, pp. 18882-90, (1993) (PubMed).
Bours, Franzoso, Azarenko, Park, Kanno, Brown, Siebenlist: "The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers." dans: Cell, Vol. 72, Issue 5, pp. 729-39, (1993) (PubMed).
Bours, Burd, Brown, Villalobos, Park, Ryseck, Bravo, Kelly, Siebenlist: "A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site." dans: Molecular and cellular biology, Vol. 12, Issue 2, pp. 685-95, (1992) (PubMed).
Schmid, Perkins, Duckett, Andrews, Nabel: "Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65." dans: Nature, Vol. 352, Issue 6337, pp. 733-6, (1991) (PubMed).
Antigène
NFKB2
(Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2))
anticorps NF-kappaB2, anticorps lyt, anticorps p49, anticorps p49/p100, anticorps p50B, anticorps p52, anticorps nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100, anticorps Nfkb2
Sujet
NFKB2 (Nuclear factor NF-kappa-B p100 subunit) is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappaB sites that they can bind with distinguishable affinity and specificity. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. Synonyms: LYT10(Lymphocyte translocation chromosome 10)