P70 S6 Kinase (Ab-411) antibody detects endogenous levels of total p70 S6 Kinase protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogène
The antiserum was produced against synthesized phosphopeptide derived from human p70 S6 Kinase around the phosphorylation site of serine 411 (I-R-SP-P-R).
RPS6KB1
Reactivité: Humain, Souris, Rat, Porc
WB, IHC, ELISA, IF, ICC
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
WB: 1:500~1:1000 IHC: 1:50~1:100.
Restrictions
For Research Use only
Format
Liquid
Concentration
100ug/100ul.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
-20 °C
Kulkarni, C: "Persistant unconjugated hyperbilirubinemia in an infant with crigler-najjar syndrome type I." dans: Indian pediatrics, Vol. 40, Issue 12, pp. 1209-10, (2004) (PubMed).
Le, Hittelman, Liu, McWatters, Li, Mills, Bast: "Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis." dans: Oncogene, Vol. 22, Issue 4, pp. 484-97, (2003) (PubMed).
Krause, Bertrand, Hue: "Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes." dans: European journal of biochemistry / FEBS, Vol. 269, Issue 15, pp. 3751-9, (2002) (PubMed).
Eguchi, Iwasaki, Ueno, Frank, Motley, Eguchi, Marumo, Hirata, Inagami et al.: "Intracellular signaling of angiotensin II-induced p70 S6 kinase phosphorylation at Ser(411) in vascular smooth muscle cells. Possible requirement of epidermal growth factor receptor, Ras, ..." dans: The Journal of biological chemistry, Vol. 274, Issue 52, pp. 36843-51, (2000) (PubMed).
Papst, Sugiyama, Nagasawa, Lucas, Maller, Terada: "Cdc2-cyclin B phosphorylates p70 S6 kinase on Ser411 at mitosis." dans: The Journal of biological chemistry, Vol. 273, Issue 24, pp. 15077-84, (1998) (PubMed).
Antigène
RPS6KB1
(Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1))