Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-residues of human PCNA (proliferating cell nuclear antigen)
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The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudo genes of this gene have been described on chromosome 4 and on the X chromosome.