POLB anticorps (N-Term)

N° du produit ABIN966876

Détail du produit anti-POLB anticorps

Antigène: POLB (Polymerase (DNA Directed), beta (POLB))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp POLB est non-conjugé

Application: Immunohistochemistry (IHC)

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human POLB (DNA polymerase beta)

Information d'application

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Références pour anticorps anti-POLB (ABIN966876)

El-Andaloussi, Valovka, Toueille, Steinacher, Focke, Gehrig, Covic, Hassa, Schär, Hübscher, Hottiger: "Arginine methylation regulates DNA polymerase beta." dans: Molecular cell, Vol. 22, Issue 1, pp. 51-62, (2006) (PubMed).

DeMott, Beyret, Wong, Bales, Hwang, Greenberg, Demple: "Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone." dans: The Journal of biological chemistry, Vol. 277, Issue 10, pp. 7637-40, (2002) (PubMed).

Patterson, Little, Cheng, Widen, Kumar, Beard, Wilson: "Molecular cloning and high-level expression of human polymerase beta cDNA and comparison of the purified recombinant human and rat enzymes." dans: Protein expression and purification, Vol. 18, Issue 1, pp. 100-10, (2000) (PubMed).

Matsumoto, Kim, Katz, Feng: "Catalytic center of DNA polymerase beta for excision of deoxyribose phosphate groups." dans: Biochemistry, Vol. 37, Issue 18, pp. 6456-64, (1998) (PubMed).

Dobashi, Kubota, Shuin, Torigoe, Yao, Hosaka: "Polymorphisms in the human DNA polymerase beta gene." dans: Human genetics, Vol. 95, Issue 4, pp. 389-90, (1995) (PubMed).

Chyan, Ackerman, Shepherd, McBride, Widen, Wilson, Wood: "The human DNA polymerase beta gene structure. Evidence of alternative splicing in gene expression." dans: Nucleic acids research, Vol. 22, Issue 14, pp. 2719-25, (1994) (PubMed).

Widen, Kedar, Wilson: "Human beta-polymerase gene. Structure of the 5'-flanking region and active promoter." dans: The Journal of biological chemistry, Vol. 263, Issue 32, pp. 16992-8, (1988) (PubMed).

Abbotts, SenGupta, Zmudzka, Widen, Notario, Wilson: "Expression of human DNA polymerase beta in Escherichia coli and characterization of the recombinant enzyme." dans: Biochemistry, Vol. 27, Issue 3, pp. 901-9, (1988) (PubMed).

SenGupta, Zmudzka, Kumar, Cobianchi, Skowronski, Wilson: "Sequence of human DNA polymerase beta mRNA obtained through cDNA cloning." dans: Biochemical and biophysical research communications, Vol. 136, Issue 1, pp. 341-7, (1986) (PubMed).

Détails sur POLB

Antigène: POLB (Polymerase (DNA Directed), beta (POLB))

Autre désignation: POLB (POLB Produits)

Synonymes: anticorps wu:fa97a05, anticorps zgc:109924, anticorps POLB, anticorps DDBDRAFT_0186152, anticorps DDBDRAFT_0215784, anticorps DDBDRAFT_0232376, anticorps DDB_0186152, anticorps DDB_0215784, anticorps DDB_0232376, anticorps A430088C08Rik, anticorps polymerase (DNA directed), beta, anticorps DNA polymerase beta, anticorps DNA polymerase X family protein, anticorps polymerase (DNA directed), beta S homeolog, anticorps polb, anticorps POLB, anticorps polB, anticorps polb.S, anticorps Polb

Sujet: POLB (DNA polymerase beta) is a repair polymerase. POLB conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. POLB has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. POLB binds 2 magnesium ions per subunit (By similarity).POLB belongs to the DNA polymerase type-X family.

Pathways: Réparation de l'ADN